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Article

Classical NF-κB pathway is responsible for APOBEC3B expression in cancer cells

1 Sept 2016

Abstract excerpt

APOBEC3B (A3B) is a DNA cytosine deaminase and catalyzes cytosine deamination, resulting in mutations in genomic DNA. A3B is aberrantly expressed in a variety of cancers and considered to be a source of genomic mutations that contribute to cancer progression and metastasis. However, the mechanisms through which A3B expression is dysregulated in cancer cells are not fully elucidated. Here we report that the...

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PMID: 27577680
DOI: 10.1016/j.bbrc.2016.08.148

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