Article
Polymorphism in the MAGI2 Gene Modifies the Effect of Amyloid β on Neurodegeneration.
Alzheimer disease and associated disorders - 1 Jan 2000
Kim Hang-Rai, Lee Taeyeop, Choi Jung K, Jeong Yong
Abstract excerpt
INTRODUCTION: A weak association between amyloid β (Aβ) deposition and neurodegeneration biomarkers, such as brain atrophy, has been repeatedly reported in a subset of patients with Alzheimer disease, suggesting individual differences in response to Aβ deposition. METHODS: Here, we performed a genome-wide interaction study to identify single-nucleotide polymorphism (SNP) that modify the effect of Aβ (measured by...
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