Article
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.
Human molecular genetics - 1 Nov 2003
Saunders Aleister J, Bertram Lars, Mullin Kristina, Sampson Andrew J, Latifzai Khushal, Basu Sanjay, Jones Jennifer, Kinney Devon, MacKenzie-Ingano Laura, Yu Stephen, Albert Marilyn S, Moscarillo Thomas J, Go Rodney C P, Bassett Susan S, Daly Mark J, Laird Nan M, Wang Xin, Velicelebi Gonul, Wagner Steven L, Becker David K, Tanzi Rudolph E, Blacker Deborah
Abstract excerpt
Alpha-2-Macroglobulin (A2M) is a highly plausible candidate gene for Alzheimer's disease (AD) in a region of chromosome 12 that has numerous independent reports of genetic linkage. We previously reported that a 5 bp deletion in A2M was associated with AD in a subset of the National Institute of Health (NIMH) Genetics Initiative AD family sample. Efforts to replicate this association finding in case - control...
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