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Novel<i>CYP1B1-RMDN2</i>Alzheimer’s disease locus identified by genome-wide association analysis of cerebral tau deposition on PET

2023-03-01

Abstract excerpt

Determining the genetic architecture of Alzheimer’s disease (AD) pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we performed a genome-wide association study of cortical tau quantified by positron emission tomography in 3,136 participants from 12 independent studies. The CYP1B1-RMDN2 locus was associated with tau deposition. The most significant signal was at rs211...

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Literature Corpus work
fa0eedd9-19c6-5288-8388-b0a062539efe
DOI
10.1101/2023.02.27.23286048
Open publication

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Novel<i>CYP1B1-RMDN2</i>Alzheimer’s disease locus identified by genome-wide association analysis of cerebral tau deposition on PETDOI 10.1101/2023.02.27.23286048
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