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Inhibiting Bacterial Fatty Acid Synthesis

29 Apr 2006

Abstract excerpt

The type II fatty acid synthase consists of a series of individual enzymes, each encoded by a separate gene, that catalyze discrete steps in chain elongation. The formation of fatty acids is vital to bacteria, and each of the essential enzymes and their acyl group carriers represent a potential target for the development of novel antibacterial therapeutics. High resolution x-ray and/or NMR structures of...

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PMID: 16648134
DOI: 10.1074/jbc.r600004200

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