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Genome-wide Copy-number Alterations in Circulating Tumor DNA as a Novel Biomarker for Patients with High-grade Serous Ovarian Cancer

15 Dec 2020

Abstract excerpt

Abstract Purpose: High-grade serous epithelial ovarian cancer (HGS-EOC) is defined by high levels of somatic copy-number alterations (SCNA) with marked spatial and temporal tumor heterogeneity. Biomarkers serving to monitor drug response and detect disease recurrence are lacking, a fact which reflects an unmet clinical need. Experimental Design: A total of 185 plasma samples and 109 matched tumor biopsies were...

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Cancer Genomics and Diagnostics
Genomic variations and chromosomal abnormalities
Ovarian cancer diagnosis and treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33323403
DOI: 10.1158/1078-0432.ccr-20-3345

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