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Article

Phenotypic and genotypic characterization of single circulating tumor cells in the follow-up of high-grade serous ovarian cancer.

Molecular oncology - 1 Jun 2026

Salmon Carolin, Neves Rui P L, Stoecklein Nikolas H, Liffers Sven-Thorsten, Siveke Jens, Kuhlmann Jan D, Wimberger Pauline, Buderath Paul, Kimmig Rainer, Kasimir-Bauer Sabine

Abstract excerpt

Single circulating tumor cell (sCTC) analysis enables the determination of predominant CTC phenotypes and genotypes. We previously demonstrated the feasibility of sCTC detection and genomic characterization in high-grade serous ovarian cancer (HGSOC) by combining immune-magnetic enrichment and image-based sorting, followed by whole-genome amplification (WGA) and next-generation sequencing-based copy number...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41437733
DOI: 10.1002/1878-0261.70193
PMCID: PMC13238577

Genes

ALK
CDK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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