Article
Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea.
Malaria journal - 19 Oct 2021
Yoshida Naoko, Yamauchi Masato, Morikawa Ryosuke, Hombhanje Francis, Mita Toshihiro
Abstract excerpt
BACKGROUND: The C580Y mutation in the Plasmodium falciparum kelch13 gene is the most commonly observed variant in artemisinin-resistant isolates in the Greater Mekong Subregion (GMS). Until 2017, it had not been identified outside the GMS, except for Guyana/Amazonia. In 2017, three parasites carrying the C580Y mutation were identified in Papua New Guinea (PNG). As the C580Y allele rapidly spread in the GMS, there...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.