Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT

10 Apr 2018

Abstract excerpt

Glioblastoma multiforme (GBM) is the most malignant brain tumour and is associated with poor prognosis due to its thorny localization, lack of efficacious therapies, and complex biology. Among the numerous pathways driving GBM biology studied so far, PTEN/PI3K/AKT/mTOR signalling plays a pivotal role, as it controls cell survival, proliferation and metabolism and is involved in stem cell maintenance. In front of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to CRISPR and Genetic Engineering
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29692710
DOI: 10.3389/fncel.2018.00099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKTPMID 29692710Read ↗

Targeting mTOR in Glioblastoma: Rationale and Preclinical/Clinical EvidenceSemantic proximity Read ↗

mTOR-Dependent Cell Proliferation in the BrainSemantic proximity Read ↗

PTEN deficiency leads to proteasome addiction: a novel vulnerability in glioblastomaSemantic proximity Read ↗

Combined PI3Kα-mTOR Targeting of Glioma Stem CellsSemantic proximity Read ↗

The Autophagy Status of Cancer Stem Cells in Gliobastoma Multiforme: From Cancer Promotion to Therapeutic StrategiesSemantic proximity Read ↗

The Akt/mTOR pathway in cancer stem/progenitor cells is a potential therapeutic target for glioblastoma and neuroblastomaSemantic proximity Read ↗

ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma.Semantic proximity Read ↗

mTOR signaling in glioblastoma: lessons learned from bench to bedsideSemantic proximity Read ↗

Emerging targets for glioblastoma stem cell therapySemantic proximity Read ↗

PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastomaSemantic proximity Read ↗

A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma TherapySemantic proximity Read ↗

Targeting the AKT Pathway in GlioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.