Article
Somatic mutations of PIK3R1 promote gliomagenesis.
PloS one - 1 Jan 2012
Quayle Steven N, Lee Jennifer Y, Cheung Lydia W T, Ding Li, Wiedemeyer Ruprecht, Dewan Robert W, Huang-Hobbs Emmet, Zhuang Li, Wilson Richard K, Ligon Keith L, Mills Gordon B, Cantley Lewis C, Chin Lynda
Abstract excerpt
The phosphoinositide 3-kinase (PI3K) pathway is targeted for frequent alteration in glioblastoma (GBM) and is one of the core GBM pathways defined by The Cancer Genome Atlas. Somatic mutations of PIK3R1 are observed in multiple tumor types, but the tumorigenic activity of these mutations has not been demonstrated in GBM. We show here that somatic mutations in the iSH2 domain of PIK3R1 act as oncogenic driver...
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