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Article

mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.

Neoplasia (New York, N.Y.) - 1 Apr 2005

Hu Xiaoyi, Pandolfi Pier Paolo, Li Yi, Koutcher Jason A, Rosenblum Marc, Holland Eric C

Abstract excerpt

Combined activation of Ras and AKT leads to the formation of astrocytic glioblastoma multiforme (GBM) in mice. In human GBMs, AKT is not mutated but is activated in approximately 70% of these tumors, in association with loss of PTEN and/or activation of receptor tyrosine kinases. Mechanistic just...

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Share to Glioblastoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoric Monoester Hydrolases

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

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Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 15967113
DOI: 10.1593/neo.04595
PMCID: PMC1501155

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15967113-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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