Article
Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans.
PloS one - 1 Jan 2011
Lee Mary R, Gallen Courtney L, Zhang Xiaochu, Hodgkinson Colin A, Goldman David, Stein Elliot A, Barr Christina S
Abstract excerpt
Previous reports on the functional effects (i.e., gain or loss of function), and phenotypic outcomes (e.g., changes in addiction vulnerability and stress response) of a commonly occurring functional single nucleotide polymorphism (SNP) of the mu-opioid receptor (OPRM1 A118G) have been inconsistent. Here we examine the effect of this polymorphism on implicit reward learning. We used a probabilistic signal...
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