Article
Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2021
Meziane Oussama, Alexandrova Yulia, Olivenstein Ronald, Dupuy Franck P, Salahuddin Syim, Thomson Elaine, Orlova Marianna, Schurr Erwin, Ancuta Petronela, Durand Madeleine, Chomont Nicolas, Estaquier Jérôme, Bernard Nicole F, Costiniuk Cecilia T, Jenabian Mohammad-Ali
Abstract excerpt
People living with HIV have high burdens of chronic lung disease, lung cancers, and pulmonary infections despite antiretroviral therapy (ART). The rates of tobacco smoking by people living with HIV vastly exceed that of the general population. Furthermore, we showed that HIV can persist within the lung mucosa despite long-term ART. As CD8 T cell cytotoxicity is pivotal for controlling viral infections and...
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