Article
Diminished Peripheral CD29hi Cytotoxic CD4+ T Cells Are Associated With Deleterious Effects During SIV Infection.
Frontiers in immunology - 1 Jan 2021
Olwenyi Omalla A, Johnson Samuel D, Pandey Kabita, Thurman Michellie, Acharya Arpan, Buch Shilpa J, Fox Howard S, Podany Anthony T, Fletcher Courtney V, Byrareddy Siddappa N
Abstract excerpt
Cytotoxic CD4+ T cells (CD4+ CTLs) limit HIV pathogenesis, as evidenced in elite controllers (a subset of individuals who suppress the virus without the need for therapy). CD4+ CTLs have also been shown to kill HIV-infected macrophages. However, little is known about their contribution towards HIV persistence, how they are affected following exposure to immune modulators like morphine, and what factors maintain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.