Article
Thioredoxin deficiency exacerbates vascular dysfunction during diet-induced obesity in small mesenteric artery in mice.
Microcirculation (New York, N.Y. : 1994) - 1 May 2021
Dunn Shannon, Hilgers Robert H, Das Kumuda C
Abstract excerpt
OBJECTIVE: Thioredoxin (Trx) is a small cellular redox protein with established antioxidant and disulfide reductase properties. We hypothesized that Trx deficiency in mice would cause increased oxidative stress with consequent redox imbalance that would exacerbate obesity-induced vascular dysfunction. METHODS: Non-transgenic (NT, C57BL/6) and dominant-negative Trx (dnTrx-Tg, low levels of redox-active protein)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.