Article
An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects.
The Journal of clinical endocrinology and metabolism - 1 Aug 2011
Das Swapan K, Sharma Neeraj K, Hasstedt Sandra J, Mondal Ashis K, Ma Lijun, Langberg Kurt A, Elbein Steven C
Abstract excerpt
CONTEXT: Obesity is a complex disease that involves both genetic and environmental perturbations to gene networks in adipose tissue and is proposed as a trigger for metabolic sequelae. OBJECTIVE: We hypothesized that expression of adipose tissue transcripts in gene networks for adaptive response would correlate with the percent fat mass (PFAT) in healthy nondiabetic subjects to maintain metabolic equilibrium and...
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