Article

Exogenous Thyroxine Increases Cardiac Nrf2-TRX Associated with a Reduction in Oxidative Injury and Inflammation in Insulin Resistant OLETF Rats

2025-04-23

Abstract excerpt

Cardiovascular disease (CVD) is the leading cause of death among individuals with Type II diabetes (T2D), affecting approximately 30 million people in the United States. During insulin resistance, the heart undergoes a metabolic shift, leading to increased reactive oxygen species (ROS) generation, lipotoxicity, and mitochondrial dysfunction, ultimately contributing to cardiovascular dysfunction. The effects of thy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c276a2fa-0bd6-59a0-88fb-0fe340d6444a
DOI: 10.1101/2025.04.16.649239

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exogenous Thyroxine Increases Cardiac Nrf2-TRX Associated with a Reduction in Oxidative Injury and Inflammation in Insulin Resistant OLETF RatsDOI 10.1101/2025.04.16.649239Read

Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic CardiomyopathySemantic proximity Read

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in MiceSemantic proximity Read

Inhibition of endoplasmic reticulum stress ameliorates cardiovascular injury in a rat model of metabolic syndrome.Semantic proximity Read

WITHDRAWN: Endurance Training Alleviates Metabolic-associated Fatty-liver Disease (MAFLD)-related Testicular Impairments via ER Stress RegulationSemantic proximity Read

The heme oxygenase system selectively enhances the anti-inflammatory macrophage-M2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in Zucker diabetic fatty rats.Semantic proximity Read

The Dark Side of Nrf2 in the HeartSemantic proximity Read

Peroxiredoxin 4 (PRDX4): Its Critical <em>In Vivo</em> Roles in Animal Models of Metabolic Syndrome Using Our Unique PRDX4 Transgenic MiceSemantic proximity Read

TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.Semantic proximity Read

Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat.Semantic proximity Read

A cocktail of B vitamins with nicotinamide riboside, folate and cobalamin preserves cardiac function and mitochondrial oxidative capacities in a mouse model of heart failureSemantic proximity Read

Novel Oral-edaravone Attenuates Diastolic Dysfunction of Diabetic Cardiomyopathy via Activating the Nrf2 Signaling PathwaySemantic proximity Read

TUDCA treatment restores aortic and perivascular adipose tissue function in post-weaning protein-restricted miceSemantic proximity Read