Kinetics of tamoxifen‐regulated Cre activity in mice using a cartilage‐specific CreER^T to assay temporal activity windows along the proximodistal limb skeleton

Abstract excerpt

Cartilage differentiation occurs over a broad time range from early embryonic development, when the mesenchymal condensations that give rise to cartilage models for future bone first appear, and continuing through adult life, when there is ongoing maintenance of articular joint surfaces and re-activation of cartilage formation after fracture. The chondrogenic response also figures in the pathogenesis of...

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