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Generation of aggrecan‐CreERT2 knockin mice for inducible Cre activity in adult cartilage

14 Oct 2009

Abstract excerpt

The function of cartilage in the adult is dependent on a host of regulatory molecules such as growth factors, extracellular matrix, enzymes, signaling molecules, and transcription factors. However, germline mutations in some genes that are expressed in adult cartilage lead to embryonic or perinatal lethality. To examine the function of these and other genes postnatally, we have generated a targeted mouse by...

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PMID: 19830818
DOI: 10.1002/dvg.20564

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