Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A computational approach to analyse the amino acid variants of GLB1 protein causing GM1 Gangliosidosis.

Metabolic brain disease - 1 Mar 2021

Priyanka K, Madhana Priya N, Magesh R

Abstract excerpt

Lysosomal storage diseases comprise different forms of autosomal recessive disorders from which GM1 gangliosidosis has categorized by the accumulation of complex glycolipids associated with a range of progressive neurologic phenotypes. GM1 gangliosidosis is an inherited disorder that progressively destroys nerve cells (neurons) in the brain and spinal cord. GM1 has three main types of onsets, namely infantile...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to beta-Galactosidase
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gangliosidosis, GM1

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Mutation

Share to Phenotype

Source

Identifiers

PMID: 33394287
DOI: 10.1007/s11011-020-00650-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A computational approach to analyse the amino acid variants of GLB1 protein causing GM1 Gangliosidosis.PMID 33394287Read ↗

In-silico screening and microsecond molecular dynamics simulations to identify single point mutations that destabilize β-hexosaminidase A causing Tay-Sachs disease.Semantic proximity Read ↗

SAAMP 2.0: An algorithm to predict genotype-phenotype correlation of lysosomal storage diseases.Semantic proximity Read ↗

Structural and dynamics insights into the GBA variants associated with Parkinson's disease.Semantic proximity Read ↗

Insilico Analysis Reveal Three novel nsSNPs May effect on <i>GM2A</i> protein Leading to AB variant of GM2 gangliosidosisSemantic proximity Read ↗

An Integrated Computational Framework to Assess the Mutational Landscape of α-L-Iduronidase IDUA Gene.Semantic proximity Read ↗

Thirty two novel nsSNPs May effect on <i>HEXA</i> protein Leading to Tay-Sachs disease (TSD) Using a Computational ApproachSemantic proximity Read ↗

Computational modelling approaches as a potential platform to understand the molecular genetics association between Parkinson's and Gaucher diseases.Semantic proximity Read ↗

P. Ala278Val mutation might cause a pathogenic defect in HEXB folding leading to the Sandhoff disease.Semantic proximity Read ↗

Pyrimethamine-based targeting of HEXA gene mutations in Tay-Sachs disease: a computational analysisSemantic proximity Read ↗

Structural Analysis of G1691S Variant in the Human Filamin B Gene Responsible for Larsen Syndrome: A Comparative Computational Approach.Semantic proximity Read ↗

Computational Approaches for Investigating Disease-causing Mutations in Membrane Proteins: Database Development, Analysis and Prediction.Semantic proximity Read ↗

Elucidating the functional impact of G137V and G144R variants in Maroteaux Lamy's Syndrome by Molecular Dynamics Simulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.