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Simulation and Computational Study of RING Domain Mutants of BRCA1 and Ube2k in AD/PD Pathophysiology.

Molecular biotechnology - 1 May 2024

Sahu Mehar, Rani Neetu, Kumar Pravir

Abstract excerpt

Lysine-based post-translational modification (PTM) such as acylation, acetylation, deamination, methylation, SUMOylation, and ubiquitination has proven to be a major regulator of gene expression, chromatin structure, protein stability, protein-protein interaction, protein degradation, and cellular localization. However, besides all the PTMs, ubiquitination stands as the second most common PTM after...

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PMID: 38172369
DOI: 10.1007/s12033-023-01006-4

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