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Functional roles and cancer variants of the bifunctional glycosylase NEIL2

13 Jun 2023

Abstract excerpt

Over 70,000 DNA lesions occur in the cell every day, and the inability to properly repair them can lead to mutations and destabilize the genome, resulting in carcinogenesis. The base excision repair (BER) pathway is critical for maintaining genomic integrity by repairing small base lesions, abasic sites and single-stranded breaks. Monofunctional and bifunctional glycosylases initiate the first step of BER by...

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PMID: 37310399
DOI: 10.1002/em.22555

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