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Article

Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.

Developmental cell - 19 Apr 2011

Vitobello Antonio, Ferretti Elisabetta, Lampe Xavier, Vilain Nathalie, Ducret Sebastien, Ori Michela, Spetz Jean-François, Selleri Licia, Rijli Filippo M

Abstract excerpt

In vertebrate embryos, retinoic acid (RA) synthesized in the mesoderm by Raldh2 emanates to the hindbrain neuroepithelium, where it induces anteroposterior (AP)-restricted Hox expression patterns and rhombomere segmentation. However, how appropriate spatiotemporal RA activity is generated in the hindbrain is poorly understood. By analyzing Pbx1/Pbx2 and Hoxa1/Pbx1 null mice, we found that Raldh2 is itself under...

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Identifiers

PMID: 21497760
DOI: 10.1016/j.devcel.2011.03.011
PMCID: PMC3677862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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