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Article

Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development.

Developmental biology - 1 Nov 2010

Lee Young Jae, McPherron Alexandra, Choe Susan, Sakai Yasuo, Chandraratna Roshantha A, Lee Se-Jin, Oh S Paul

Abstract excerpt

Mice deficient in growth differentiation factor 11 (GDF11) signaling display anterior transformation of axial vertebrae and truncation of caudal vertebrae. However, the in vivo molecular mechanisms by which GDF11 signaling regulates the development of the vertebral column have yet to be determined. We found that Gdf11 and Acvr2b mutants are sensitive to exogenous RA treatment on vertebral specification and caudal...

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Identifiers

PMID: 20801112
DOI: 10.1016/j.ydbio.2010.08.022
PMCID: PMC2967481

Genes

GDF11

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