Article
Germline variation networks in the PI3K/AKT pathway corresponding to familial high-incidence lung cancer pedigrees.
BMC cancer - 9 Dec 2020
Lin Huan, Zhang Gong, Zhang Xu-Chao, Lian Xin-Lei, Zhong Wen-Zhao, Su Jian, Chen Shi-Liang, Wu Yi-Long
Abstract excerpt
BACKGROUND: There were scarcely germline variants of familial lung cancer (LC) identified. We conducted an study with whole-exome sequencing of pedigrees with familial lung cancer to analyze the potential genetic susceptibility. METHODS: Probands with the highest hereditary background were identified by our large-scale epidemiological study and five ones were enrolled as a learning set. The germline SNPs...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.