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Article

Quantile-specific heritability of total cholesterol and its pharmacogenetic and nutrigenetic implications.

International journal of cardiology - 15 Mar 2021

Williams Paul T

Abstract excerpt

BACKGROUND: "Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. cholesterol) is high or low relative to its distribution. We have previously shown that the effect of a 52-SNP genetic-risk score was 3-fold larger at the 90th percentile of the total cholesterol distribution than at its 10th percentile. The objective of this study is to assess...

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Identifiers

PMID: 33296721
DOI: 10.1016/j.ijcard.2020.11.070
PMCID: PMC7897293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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