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Quantile-specific heritability of high-density lipoproteins with implications for precision medicine

29 May 2020

Abstract excerpt

Background We have previously shown that the effect of a high-density lipoprotein (HDL) genetic risk score depends on whether the phenotype (HDL cholesterol) is high or low relative to its distribution (quantile-dependent expressivity). Objective Evidence for quantile-dependent expressivity was sought using a more inclusive genetic measure (quantile-specific heritability, h 2 ) in a larger population (Framingham...

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PMID: 32600822
DOI: 10.1016/j.jacl.2020.05.099

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