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Article

Quantile-Dependent Expressivity and Gene-Lifestyle Interactions Involving High-Density Lipoprotein Cholesterol.

Lifestyle genomics - 1 Jan 2021

Williams Paul T

Abstract excerpt

BACKGROUND: The phenotypic expression of a high-density lipoprotein (HDL) genetic risk score has been shown to depend upon whether the phenotype (HDL-cholesterol) is high or low relative to its distribution in the population (quantile-dependent expressivity). This may be due to the effects of genetic mutations on HDL-metabolism being concentration dependent. METHOD: The purpose of this article is to assess...

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Identifiers

PMID: 33296900
DOI: 10.1159/000511421
PMCID: PMC8116986

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