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Article

Quantile-specific heritability of sibling leptin concentrations and its implications for gene-environment interactions.

Scientific reports - 17 Dec 2020

Williams Paul T

Abstract excerpt

"Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g., leptin) is high or low relative to its distribution. Leptin concentrations are strongly related to adiposity, whose heritability is quantile dependent. Whether inheritance of leptin concentrations is quantile dependent, and whether this explains the greater heritability in women than men in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33335207
DOI: 10.1038/s41598-020-79116-1
PMCID: PMC7747738

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