Article
TGFB1 polymorphisms and TGF-β1 plasma levels identify gastric adenocarcinoma patients with lower survival rate and disseminated disease.
Journal of cellular and molecular medicine - 1 Jan 2021
Juarez Ignacio, Gutierrez Alberto, Vaquero-Yuste Christian, Molanes-López Elisa M, López Adela, Lasa Inmaculada, Gómez Remedios, Martin-Villa José Manuel
Abstract excerpt
TGF-β1 is involved in tumour growth. Four TGFB1 SNPs and TGF-β1 production by stimulated PBMC were determined in seventy-eight gastric adenocarcinoma patients. In addition, TGF-β1 levels were measured in the plasma of further thirty patients. rs1800471-G/C genotype was prevalent in patients (20.7%) compared to controls (8.4%), as it also was the rs1800468 SNP-G/A genotype in stage IV patients (20.7%) compared to...
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