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Article

Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer.

Nature communications - 1 Jan 2014

Liu Shixuan, Cheng Wei, Fowle Grider Ronald, Shen Guomin, Li Weikai

Abstract excerpt

The intramembrane vitamin K epoxide reductase (VKOR) supports blood coagulation in humans and is the target of the anticoagulant warfarin. VKOR and its homologues generate disulphide bonds in organisms ranging from bacteria to humans. Here, to better understand the mechanism of VKOR catalysis, we report two crystal structures of a bacterial VKOR captured in different reaction states. These structures reveal a...

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Identifiers

PMID: 24477003
DOI: 10.1038/ncomms4110
PMCID: PMC4360977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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