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Article

The vitamin K cycle.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2005

Stafford D W

Abstract excerpt

Post-translational modification of glutamate to gamma carboxyl glutamate is required for the activity of vitamin K-dependent proteins. Carboxylation is accomplished by the enzyme gamma glutamyl carboxylase (GGCX) which requires the propeptide-containing substrate and three co-substrates: reduced vitamin K, CO2, and O2. Most propeptides bind tightly to GGCX and all of the Glu residues that will be modified are...

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Source

Identifiers

PMID: 16102054
DOI: 10.1111/j.1538-7836.2005.01419.x

Genes

GGCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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