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Article

Cellular and biochemical approaches to define GGCX carboxylation of vitamin K-dependent proteins.

Methods in enzymology - 1 Jan 2024

Berkner Kathleen L, Hallgren Kevin W, Rishavy Mark A, Runge Kurt W

Abstract excerpt

The gamma-glutamyl carboxylase (GGCX) generates clusters of carboxylated glutamic acid residues in vitamin K-dependent (VKD) proteins, which is required for their diverse functions including hemostasis and regulation of calcification. The GGCX modifies a VKD protein using several substrates and cofactors, and has regulatory mechanisms like processivity that ensures full carboxylation of VKD proteins. The GGCX...

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Source

Identifiers

PMID: 39572139
DOI: 10.1016/bs.mie.2024.10.023

Genes

GGCX
VKORC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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