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Article

Silencing of the Long Noncoding RNA MYCNOS1 Suppresses Activity of MYCN-Amplified Retinoblastoma Without RB1 Mutation.

Investigative ophthalmology & visual science - 1 Dec 2020

Saengwimol Duangporn, Chittavanich Pamorn, Laosillapacharoen Natanan, Srimongkol Atthapol, Chaitankar Vijender, Rojanaporn Duangnate, Aroonroch Rangsima, Suktitipat Bhoom, Saisawang Chonticha, Svasti Saovaros, Hongeng Suradej, Kaewkhaw Rossukon

Abstract excerpt

Purpose: MYCNOS (MYCN opposite strand) is co-amplified with MYCN in pediatric cancers, including retinoblastoma. MYCNOS encodes several RNA variants whose functions have not been elucidated in retinoblastoma. Thus, we attempted to identify MYCNOS variants in retinoblastoma and aimed to decipher the role of MYCNOS variant 1 (MYCNOS1) on the activity of MYCN-amplified retinoblastoma. Methods: The profiles of MYCNOS...

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Identifiers

PMID: 33270844
DOI: 10.1167/iovs.61.14.8
PMCID: PMC7718827

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