Role of MYCN in retinoblastoma: A review of current literature.

doi:10.1016/j.survophthal.2024.05.009

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Article

Role of MYCN in retinoblastoma: A review of current literature.

Survey of ophthalmology - 1 Jan 2000

Vempuluru Vijitha S, Maniar Arpita, Bakal Komal, Kaliki Swathi

Abstract excerpt

Chromosomal abnormalities that involve the MYCN gene are rare; however, it is one of the most commonly mutated genes in retinoblastoma (RB) after the RB1 gene. MYCN is amplified in approximately 1-9 % of all RB tumors. It plays a role in RB oncogenesis via many mechanisms, including synergism with RB1 deletion, positive feedback with MDM2, upregulation of cell cycle regulating genes, upregulation of miRNA, and...

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PMID: 38796108
DOI: 10.1016/j.survophthal.2024.05.009

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