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A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma

30 Jul 2024

Abstract excerpt

Retinoblastoma are childhood eye tumors arising from retinal precursor cells. Two distinct retinoblastoma subtypes with different clinical behavior have been described based on gene expression and methylation profiling. Using consensus clustering of DNA methylation analysis from 61 retinoblastomas, we identify a MYCN-driven cluster of subtype 2 retinoblastomas characterized by DNA hypomethylation and high...

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PMID: 39079981
DOI: 10.1038/s42003-024-06596-6

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