Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYCN Amplification in RB1-Inactivated Retinoblastoma: Association With High-Risk Features.

Pediatric blood & cancer - 1 Jun 2026

Papaioannou Kyriaki, Kubica Regina, Fischhuber Karen, Beygo Jasmin, Reschke Madlen, Ritter-Sovinz Petra, Biewald Eva, Ketteler Petra, Lohmann Dietmar, Kanber Deniz

Abstract excerpt

BACKGROUND: MYCN amplification occurs in a subset of retinoblastoma cases, both with and without RB1 inactivation. It has been suggested that retinoblastomas with MYCN amplification represent a distinct entity with more aggressive clinical behavior. METHODS: We examined the incidence of MYCN gain/amplification and RB1 inactivation in 192 unilateral retinoblastoma samples from children enucleated between 2011 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to N-Myc Proto-Oncogene Protein

Share to Retinal Neoplasms

Share to Retinoblastoma

Share to Retinoblastoma Binding Proteins

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 41924959
DOI: 10.1002/1545-5017.70297

Genes

MYCN
RB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYCN Amplification in RB1-Inactivated Retinoblastoma: Association With High-Risk Features.PMID 41924959Read ↗

Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.Semantic proximity Read ↗

Role of MYCN in retinoblastoma: A review of current literature.Semantic proximity Read ↗

High-Level MYCN-Amplified RB1-Proficient Retinoblastoma Tumors Retain Distinct Molecular SignaturesSemantic proximity Read ↗

Retinoblastoma with MYCN Amplification Diagnosed from Cell-Free DNA in the Aqueous HumorSemantic proximity Read ↗

Secondary enucleated retinoblastoma with MYCN amplification.Semantic proximity Read ↗

MYCN amplification levels in primary retinoblastoma tumors analyzed by Multiple Ligation-dependent Probe AmplificationSemantic proximity Read ↗

Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progressionSemantic proximity Read ↗

Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes.Semantic proximity Read ↗

Heterogeneity in retinoblastoma: a tale of molecules and modelsSemantic proximity Read ↗

Genetics of Retinoblastoma: An Overview and Significance of Genetic Testing in Clinical PracticeSemantic proximity Read ↗

Recent progress in retinoblastoma: Pathogenesis, presentation, diagnosis and managementSemantic proximity Read ↗

Clinical characteristics and germline mutation spectrum of RB1 in Chinese patients with retinoblastoma: A dual-center study of 145 patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.