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Article

MiR-378a-3p Promotes Macrophage Polarization from M1 to M2 for Cardiac Repair after Infarction Via Trem1.

Journal of cardiovascular translational research - 11 Jul 2026

Shen Ming, Li Tongxuan, Jiang Xuan, Wang Zichang, Liu Ningbo, Wu Peihong, Wang Gang, Zheng Mingqi

Abstract excerpt

Acute myocardial infarction (AMI) triggers a robust inflammatory response in which macrophage polarization critically influences cardiac repair, yet the regulatory role of microRNAs remains largely undefined. Through integrated analysis of GEO datasets and experimental validation in hypoxic Raw264.7 cells and a mouse AMI model, we identified that miR-378a-3p is significantly downregulated following ischemic...

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PMID: 42436353
DOI: 10.1007/s12265-026-10815-2

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