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Article

Downregulation of Mitochondrial TSPO Inhibits Mitophagy and Reduces Enucleation during Human Terminal Erythropoiesis.

International journal of molecular sciences - 28 Nov 2020

Moras Martina, Hattab Claude, Gonzalez-Menendez Pedro, Martino Suella, Larghero Jerome, Le Van Kim Caroline, Kinet Sandrina, Taylor Naomi, Lefevre Sophie D, Ostuni Mariano A

Abstract excerpt

Translocator protein (TSPO) and voltage dependent anion channels (VDAC) are two proteins forming a macromolecular complex in the outer mitochondrial membrane that is involved in pleiotropic functions. Specifically, these proteins were described to regulate the clearance of damaged mitochondria by selective mitophagy in non-erythroid immortalized cell lines. Although it is well established that erythroblast...

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Identifiers

PMID: 33260618
DOI: 10.3390/ijms21239066
PMCID: PMC7730461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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