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Article

DMT1-mutant erythrocytes have shortened life span, accelerated glycolysis and increased oxidative stress.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2014

Zidova Zuzana, Kapralova Katarina, Koralkova Pavla, Mojzikova Renata, Dolezal Dalibor, Divoky Vladimir, Horvathova Monika

Abstract excerpt

BACKGROUND/AIMS: Deficiency of the divalent metal transporter 1 (DMT1) leads to hypochromic microcytic anemia. We have previously shown that DMT1 deficiency impairs erythroid differentiation and induces apoptosis of erythroid cells. Here we analyzed metabolic processes and survival of mature erythrocytes in order to address potential involvement of erythrocyte defect in the pathophysiology of the disease....

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Identifiers

PMID: 25562168
DOI: 10.1159/000369665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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