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Article

A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation.

PloS one - 1 Jan 2015

Wölwer Christina B, Pase Luke B, Pearson Helen B, Gödde Nathan J, Lackovic Kurt, Huang David C S, Russell Sarah M, Humbert Patrick O

Abstract excerpt

Erythroid enucleation is critical for terminal differentiation of red blood cells, and involves extrusion of the nucleus by orthochromatic erythroblasts to produce reticulocytes. Due to the difficulty of synchronizing erythroblasts, the molecular mechanisms underlying the enucleation process remain poorly understood. To elucidate the cellular program governing enucleation, we utilized a novel chemical screening...

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Identifiers

PMID: 26569102
DOI: 10.1371/journal.pone.0142655
PMCID: PMC4646491

Genes

CDK9

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