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Article

Selective mitochondrial autophagy during erythroid maturation

12 Aug 2008

Abstract excerpt

Accumulating evidence suggests that autophagy can be selective in the clearance of organelles in yeast and in mammalian cells. We have observed that the sequestration of mitochondria by autophagosomes was defective in reticulocytes in the absence of Nix. Nix is required for the dissipation of mitochondrial membrane potential (DeltaPsim) during erythroid maturation. Moreover, pharmacological agents that induce the...

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Share to Autophagy in Disease and Therapy
Share to Calcium signaling and nucleotide metabolism
Share to Erythrocyte Function and Pathophysiology

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PMID: 18716457
DOI: 10.4161/auto.6716

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