Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae

doi:10.1016/j.ijantimicag.2011.02.012

Article

Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae

22 Apr 2011

Abstract excerpt

Tigecycline resistance has been attributed to ramA overexpression and subsequent acrA upregulation. The ramA locus, originally identified in Klebsiella pneumoniae, has homologues in Enterobacter and Salmonella spp. In this study, we identify in silico that the ramR binding site is also present in Citrobacter spp. and that Enterobacter, Citrobacter and Klebsiella spp. share key regulatory elements in the control...

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