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Article

Early-life stress effects on BDNF DNA methylation in first-episode psychosis and in rats reared in isolation.

Progress in neuro-psychopharmacology & biological psychiatry - 8 Jun 2021

Fachim Helene A, Corsi-Zuelli Fabiana, Loureiro Camila M, Iamjan Sri-Arun, Shuhama Rosana, Joca Samia, Menezes Paulo Rossi, Heald Adrian, Louzada-Junior Paulo, Dalton Caroline F, Del-Ben Cristina Marta, Reynolds Gavin P

Abstract excerpt

Stressful events during early-life are risk factors for psychiatric disorders. Brain-derived neurotrophic factor (BDNF) is implicated in psychosis pathophysiology and deficits in BDNF mRNA in animal models of psychiatric disease are reported. DNA methylation can control gene expression and may be influenced by environmental factors such as early-life stress. We investigated BDNF methylation in first-episode...

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Identifiers

PMID: 33259836
DOI: 10.1016/j.pnpbp.2020.110188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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