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Article

DNA methylation of BDNF as a biomarker of early-life adversity

10 Nov 2014

Abstract excerpt

Early-life adversity increases the risk for psychopathology in later life. The underlying mechanism(s) is unknown, but epigenetic variation represents a plausible candidate. Early-life exposures can disrupt epigenetic programming in the brain, with lasting consequences for gene expression and behavior. This evidence is primarily derived from animal studies, with limited study in humans due to inaccessibility of...

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PMID: 25385582
DOI: 10.1073/pnas.1408355111

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