Article
H3K9me2 regulation of BDNF expression in the hippocampus and medial prefrontal cortex is involved in the depressive-like phenotype induced by maternal separation in male rats.
Psychopharmacology - 1 Oct 2021
Jiang Zhijun, Zhu Zemeng, Zhao Mingyue, Wang Wei, Li Haonan, Liu Dexiang, Pan Fang
Abstract excerpt
BACKGROUND: Early life stress (ELS) induces a depressive-like phenotype and increases the risk of depression. Brain-derived neurotrophic factor (BDNF) has been confirmed to be involved in the pathophysiology of depression. However, the mechanism by which ELS alters the epigenetic regulation of BDNF and changes susceptibility to depression has not been fully clarified. METHODS: The present study used maternal...
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