Article
Molecular classification reveals the diverse genetic and prognostic features of gastric cancer: A multi-omics consensus ensemble clustering.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Dec 2021
Hu Xianyu, Wang Zhenglin, Wang Qing, Chen Ke, Han Qijun, Bai Suwen, Du Juan, Chen Wei
Abstract excerpt
BACKGROUND: Globally, gastric cancer (GC) is the fifth most common tumor. It is necessary to identify novel molecular subtypes to guide patient selection for specific target therapeutic benefits. METHODS: Multi-omics data, including transcriptomics RNA-sequencing (mRNA, LncRNA, miRNA), DNA methylation, and gene mutations in the TCGA-STAD cohort were used for the clustering. Ten classical clustering algorithms...
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