A framework for modeling epistatic interaction.

doi:10.1093/bioinformatics/btaa990

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Article

A framework for modeling epistatic interaction.

Bioinformatics (Oxford, England) - 19 Jul 2021

Blumenthal David B, Baumbach Jan, Hoffmann Markus, Kacprowski Tim, List Markus

Abstract excerpt

MOTIVATION: Recently, various tools for detecting single nucleotide polymorphisms (SNPs) involved in epistasis have been developed. However, no studies evaluate the employed statistical epistasis models such as the χ2-test or quadratic regression independently of the tools that use them. Such an independent evaluation is crucial for developing improved epistasis detection tools, for it allows to decide if a...

Topics

Epistasis, Genetic
Phenotype
Polymorphism, Single Nucleotide
Probability

Source

Open in PubMed

Identifiers

PMID: 33252645
DOI: 10.1093/bioinformatics/btaa990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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