Article
Dynamic analyses of Drosophila gastrulation provide insights into collective cell migration.
Science (New York, N.Y.) - 5 Dec 2008
McMahon Amy, Supatto Willy, Fraser Scott E, Stathopoulos Angelike
Abstract excerpt
The concerted movement of cells from different germ layers contributes to morphogenesis during early embryonic development. Using an optimized imaging approach and quantitative methods, we analyzed the trajectories of hundreds of ectodermal cells and internalized mesodermal cells within Drosophila embryos over 2 hours during gastrulation. We found a high level of cellular organization, with mesoderm cell...
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