Article

The immunological profile of RC17 hESC-derived dopaminergic neural progenitor cells <i>in vitro</i> : implications for the STEM-PD clinical trial

2024-01-24

Abstract excerpt

<h4>Summary</h4> Parkinson’s Disease involves the progressive loss of dopaminergic neurons (DAn), prompting clinical trials replacing cell loss with neural grafts. This includes the transplantation of pluripotent stem cell-derived DAn progenitor cells (NPC) currently under investigation in the STEM-PD trial. To determine the likelihood of immune rejection post-grafting, we characterised the immunogenicity of the...

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Literature Corpus work: 3e62a167-463c-5806-a3cc-4e71ef2743f6
DOI: 10.1101/2024.01.23.576826

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